LiCl has sufficient covalent character because of greater polarisation. Solubility of cholesterol in selected organic solvents. However, there is also the contribution of entropy to the process. Also, the structure of cholesterol doesn't lend itself to dissolving in water very well. Ionic solute dissolves in polar solvents and covalent solute dissolves in non polar solvents. Hexane is an organic solvent, and it will dissolve compounds with virtually no electronegative groups. That's why i want cholesterol which is soluble in water. Dissolution usually leads to an increase in disorder and hence an increase in entropy. Organic solvents are generally non polar as compared to polar solvents like water. Why is cholesterol more soluble in organic solvents than in water? Organic solutes tend to have many C-H bonds for instance alkanes, benzene, which are non polar due to low electronegativity differences. Your Ad Here. Kwan, * W.I. 1. Thus, cholesterol is more soluble in hexane. Research Articles Cholesterol Solubility in Organic Solvents G.L. Because of the contribution from the entropy, the overall energy change may be exothermic or endothermic. ... (0,3 mg cholesterol with 0.1-0.5 mL organic solvent) and add water to terminate the solution (99.9-99.5 mL water). Fluid Phase Equilibria, 97: 191-200. Henceit is readily soluble in non polar solvents such as acetone and ethoxyethane. Solubility of cholesterol & cholesteryl benzoate in some polar & nonpolar organic solvents. Indian J Biochem Biophys. Well, "like dissolves like" so since cholesterol is an organic compound, it is more soluble in an organic solvent. Higuchi, * A.F. Hence predominant intermolecular forces (solute-solute) are van der waals interactions. I think that the answer is generally “yes” in the sense that for a given organic amine, you can find an organic solvent in which it is soluble. It depends on the amine and the organic solvent in question. Bonds formed by the solvent (usually water) and the particles from the solid release energy. 1984 Feb;21(1):12-6. Flynn, * x Y. Shah, * S. Prakongpan, * K.H.