How statins cause muscle pain is not fully understood. Rhabdomyolysis. As such, it's recommended that the dosage of simvastatin be limited to 40 milligrams (mg) per day, which can reduce the risk of muscle problems. doi:10.1186/1476-511X-11-40, Rosenson RS, Baker SK, Jacobson TA, et al. N Engl J Med. Tongue-tie surgery is a small procedure that can help some babies with breastfeeding. 2018;7(19):e009835. Some people who take statins report having muscle pains, tenderness, or weakness. All rights reserved. For example, avoid exercising too much. According to the FDA, the following statins contain specific warnings on the package inserts about muscle pain and rhabdomyolysis: Rhabdomyolysis sounds scary, but the average statin user does not have to worry about developing this disorder. 2015;36(17):1012-1022. doi:10.1093/eurheartj/ehv043, Semple, SJ. Healthline Media does not provide medical advice, diagnosis, or treatment. Research has shown that the gene atrogin-1 may be the source of muscle pain in those taking statins. This is important because too much cholesterol in your bloodstream increases your risk of heart attack and stroke. Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Your doctor may take you off of the statin for a while to see how your body responds. Eur Heart J. Initial blood tests should include Your doctor may even prescribe a non-statin drug to help lower your cholesterol. This type of…. Lipids Health Dis. You develop: –muscle pain all over without weakness –weakness of the large muscles in the upper arms and thighs without pain, or –both muscular pain and weakness. Fevers in Children: How High Is Too High? If you have any unexplained joint or muscle pain, tenderness, or weakness while taking statins, you should call your doctor immediately. There are also things that you can do to help reduce your pain. If you have muscle weakness with or without pain, you need to contact your doctor now. You develop: –muscle pain all over without weakness –weakness of the large muscles in the upper arms and thighs without pain, or –both muscular pain and weakness. The time to find out if Medicare covers ambulance service is before you need one. In addition to severe muscle pain, rhabdomyolysis can lead to liver damage, kidney failure, and, in rare cases, death. Pink eye in babies is common but can sometimes be more serious. Rhabdomyolysis, or the breakdown of muscle tissue, is a rare side effect of statins that can also cause muscle pain. I'm on 40mg. Harvard Medical School. In rare cases, the impact of these drugs on the muscles can be serious. Yasmine S. Ali, MD, MSCI, is a board-certified preventive cardiologist and lipidologist. Sometimes switching to a different type of statin can resolve muscle-related pain and side effects, so your doctor may recommend this if you're in search of relief. While there aren't proven pain relief mechanisms for statin-related muscle pain, you may also find that gentle exercise and stretching may help., While statins are proven to help reduce cholesterol, they come with a variety of risks and side effects. About 5% to 10% of patients taking statins experience SAMS or mild muscle pain. Your risk of experiencing SAMS while taking statins is increased if you: Statin-related muscle problems are more likely to occur in people who exercise vigorously, especially if they begin to do so at a rapid rate rather than slowly building up intensity., It is also more common in people taking a variety of other medications, including Lopid (gemfibrozil), as well as steroids, cyclosporine, or niacin., Furthermore, studies have also shown that people with vitamin D deficiency also tend to experience muscle problems with statins more frequently than others. Certain factors may increase this risk. Your doctor may lower your dosage or prescribe a different statin. Statin-associated autoimmune myopathy. What is clear is that these drugs have been proved effective in treating high cholesterol. Statins also enable your liver to remove cholesterol from your blood. There are different kinds of pain, and describing the type is useful in diagnosis: recurring, constant, steady, knife-like, radiating, sharp, dull. Phys Ther. Both of these actions help to lower your total cholesterol level. If you have muscle weakness with or without pain, you need to contact your doctor now. Tasks that were once simple, such as climbing stairs or walking, may make you uncomfortable and tired while using statins. 2016;374(7):664-9. doi:10.1056/NEJMra1515161, An Overview of Muscle Pain in Statin Users, Ⓒ 2020 About, Inc. (Dotdash) — All rights reserved. J Clin Lipidol 2014; 8:S58. Like all statins, the answer is 'Yes'. They block an enzyme in your liver, which decreases the amount of cholesterol your body makes. They may suggest stopping treatment only briefly until the problem resolves, or not at all. MedlinePlus. Our website services, content, and products are for informational purposes only. Looking to start a diet to better manage your cholesterol? Statin therapy, myopathy and exercise–a case report. What Is the Medicare Diabetes Prevention Program. Most often when statins are responsible for the muscle pain, one of three things happen. Statin-associated muscle symptoms: impact on statin therapy—European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management. This disease can cause life-threatening muscle damage. 2. We explain the rules for ambulance service and Medicare. We'll give you the…, A gentle C-section, which is also called a "natural cesarean" or family-centered birth, is a surgical birth that incorporates various aspects of an…, Aetna offers a variety Medigap plans in most parts of the United States. This serious muscle wasting condition is rare and occurs in a fraction of patients. While statin-related myalgia, myositis, and rhabdomyolysis will resolve once you stop taking statins, rhabdomyolysis may result in irreversible muscle damage. Statin toxicity. Drug Saf. Updated August 9, 2019. When I have patients on statin drugs with muscle pain I do two things. While there are several theories as to why statins may cause muscle pain, none have been confirmed. Medicines that dull pain are analgesics. If you have started statins and experience muscle pain, see your doctor. One of the most common complaints of people taking statins is muscle pain. This gene turns on at the beginning stages of the breakdown of muscle, which is associated with illnesses such as cancer, sepsis, and AIDS. (When the atrogin-1 gene is not active, muscle wasting does not occur.). You may feel this pain as a soreness, tiredness or weakness in your muscles. Thank you, {{form.email}}, for signing up. Myalgia:This type of muscle pain usually feels like mild soreness in the shoulders, arms, hips or thighs. Providence Medicare Advantage: A Guide to Your 2021 Plan Options, Debra Sullivan, Ph.D., MSN, R.N., CNE, COI, What to Do If Your Baby Shows Signs of Pink Eye, What to Know If You’re Told Your Baby Needs Tongue-Tie Surgery. Dr. Ali is also an award-winning writer. Does Lipitor have any side effects? In this condition, you may experience soreness, weakness, and tiredness in muscles. Some people are more likely to develop side effects from statins, including muscle pain. If you have muscle pain while you take a statin, tell your doctor right away. When the number on thermometer starts creeping higher and higher, it's normal to wonder when a fever is too high for a child. J Am Coll Cardiol. Medicare offers a program called the Medicare Diabetes Prevention Program to…. The pain can be a mild discomfort, or it can be severe enough to make your daily activities difficult. These drugs usually aren’t effective at relieving muscle pain from statins. 2012;11(40). A person taking statins may experience muscle pains, tenderness, or weakness. 2011;215(1):23-9. doi:10.1016/j.atherosclerosis.2010.11.039, Golomb BA, Verden A, Messner AK, Koslik HJ, Hoffman KB. Atorvastatin (the generic name) and Lipitor prescription side effects are common to people taking these statins for their cholestoral lowering benefits.