It can be used to build a variety of heterocyclic compounds, some of which are potent antimicrobial and antiviral agents. Semicarbazide hydrochloride is a general reagent used to synthesize semicarbazones from aldehydes and ketones. Advanced Search | Structure Search. Experimental Melting Point: 96 °C Jean-Claude Bradley Open Melting Point Dataset 21559: Experimental Boiling Point: 186.3 °C Chemenu CM186660: Experimental LogP:-2.166 LabNetwork LN01075682: Miscellaneous. Many semicarbazones are crystalline solids, useful for the identification of the parent aldehydes/ketones by melting point analysis.[1]. 4-03-00-00177 (Beilstein Handbook Reference) [N]NC(N)=O. BBL012207. Safety: IRRITANT Matrix Scientific 045167: Some semicarbazones, such as nitrofurazone, and thiosemicarbazones are known to have anti-viral and anti-cancer activity, usually mediated through binding to copper or iron in cells. CTK1H0745. Solubility: 100 g/l (15 c) Specific Gravity/Density:Not available. BDBM50108606. Freezing/Melting Point:175.00 - 177.00 deg C Decomposition Temperature:Not available. This is an example of imine formation resulting from the reaction of a primary amine with a carbonyl group. CARBAMOHYDRAZONIC ACID. Lopac-S-2201. Many semicarbazones are crystalline solids, useful for the identification of the parent aldehydes/ketones by melting point analysis. A monocarboxylic acid amide that is urea where one of the amino groups has been replaced with hydrazine. Semicarbazones and thiosemicarbazones can be prepared by treatment of a ketone or aldehyde with semicarbazide or thiosemicarbazide (Scheme 16).The reaction is general acid catalysed, and the yield of semicarbazone and the rate of reaction are dependent on the pH of the reaction medium < 32JA2881, 59JA475, 66BSB601 >. The formation of semicarbazones from ketones can be catalysed by the … CTK1H0495. In organic chemistry, a semicarbazone is a derivative of imines formed by a condensation reaction between a ketone or aldehyde and semicarbazide. Lopac0_001096. Melting Point (°C) 101 - 200 (3) 201 - 300 (1) Application. For example, the semicarbazone of acetone would have the structure (CH3)2C=NNHC(=O)NH2. They are classified as imine derivatives because they are formed from the reaction of an aldehyde or ketone with the terminal -NH2 group of semicarbazide, which behaves very similarly to primary amines. CopyCopied, Validated by Experts, Validated by Users, Non-Validated, Removed by Users, Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, Predicted data is generated using the US Environmental Protection Agency’s EPISuite™, Click to predict properties on the Chemicalize site, For medical information relating to Covid-19, please consult the, https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28306, ACD/Labs Percepta Platform - PhysChem Module, US Environmental Protection Agency’s EPISuite™, Compounds with the same molecular formula, Search Google for structures with same skeleton. Clinical (1) ... Semicarbazide hydrochloride. Semicarbazide hydrochloride. CopyCopied, CSID:5008, http://www.chemspider.com/Chemical-Structure.5008.html (accessed 06:09, Nov 29, 2020) CopyCopied, InChI=1S/CH5N3O/c2-1(5)4-3/h3H2,(H3,2,4,5) Semicarbazide is frequently reacted with aldehydes and ketones to produce semicarbazones via a condensation reaction. Some semicarbazones, such as nitrofurazone, and thiosemicarbazones are known to have anti-viral and anti-cancer activity, usually mediated through binding to copper or iron in cells. CopyCopied, DUIOPKIIICUYRZ-UHFFFAOYSA-N It can also be used to prepare corrosion inhibitors. Compounds Containing a N-CO-N-N or More Complex Group, https://en.wikipedia.org/w/index.php?title=Semicarbazone&oldid=954547442, Creative Commons Attribution-ShareAlike License, This page was last edited on 3 May 2020, at 00:35. Boiling Point: Not available. ZINC8035043. Packaging 100, 500 g … A thiosemicarbazone is an analog of a semicarbazone which contains a sulfur atom in place of the oxygen atom.