Robays J, Nyamowala G, Sese C, et al. Sleeping sickness is caused by two different parasites, Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense . With East African trypanosomiasis, symptoms begin within 1 to 4 weeks of getting an infected tsetse fly bite. Trans R Soc Trop Med Hyg 1992; 86:630. Biéler S, Matovu E, Mitashi P, et al. The first stage, known as the hemolymphatic phase, is characterized by fever, headaches, joint pains, and itching. African trypanosomiasis, also known as sleeping sickness, is a disease spread by an infected tsetse fly, found in rural areas of sub-Saharan Africa. African Trypanosomiasis. Lumsden WH, Kimber CD, Dukes P, et al. The use of the acridine orange QBC technique in the diagnosis of African trypanosomiasis. African trypanosomiasis symptoms occur in two stages. Early diagnosis of African Trypanosomiasis is critical because of difficulties with late stage disease treatments. Both types of African trypanosomiasis cause the same generalized symptoms, including intermittent fevers, rash, and lymphadenopathy. Improved detection of Trypanosoma brucei by lysis of red blood cells, concentration and LED fluorescence microscopy. Notably, individuals with the East African form are … Field diagnosis of sleeping sickness in … Fever is intermittent, with attacks lasting from a day to a week, separated by intervals of a few days to a month or longer. The symptoms of East African trypanosomiasis develop more quickly (starting 1 month after a bite) than the symptoms of West African trypanosomiasis, which can begin months to a year after the first bite. A local infection may occur with a large 2 to 10cm red area or sore at the location of the fly’s original bite. Furthermore because the gambiense infection can have a very long asymptomatic phase, it is recommended that in areas of particular risk, the population is screened regularly for sleeping sickness to promote early diagnosis and reduce the risk of transmission  . Human African trypanosomiasis (HAT) is considered lethal without treatment, but treatment of the disease is effective. Symptoms of African trypanosomiasis (sleeping sickness) African trypanosomiasis (sleeping sickness) is divided into two stages: hemolymphatic and meningoencephalitic, or terminal (sleeping sickness in the narrow sense of the word). The incubation period varies from a few days to several weeks or months. Acta Trop 2012; 121:135. Relapses are possible and their frequency depends on the drug used and differs from one area to another, reaching up to 60% of relapses to melarsoprol in some foci in some areas. In African trypanosomiasis, diagnosis is complex since several diseases are caused by different parasites and occur in different host species giving rise to a variety of parasite-host relationships. Home; About; Incubation period, Treatments and Prognosis; How to Prevent; Bibliography; Incubation Period .