Blood clotting functions may also be checked, such as PT, PTT, and INR. Your doctor will talk to you about your results and what they mean. Aspartate transaminase (AST, formerly referred to as serum glutamic-oxaloacetic transaminase, SGOT) 3. Very high levels of AST (more than 10 times the highest normal level) are usually due to a rapidly developing liver disease called acute hepatitis, which is often due to a virus infection. Your doctor may also recommend an ultrasound or CT scan of your liver to help identify other reasons for abnormal tests. Mild elevations are generally considered to be 2 … Of the causes of liver disease, probably the single most common culprit (although not responsible for the majority of cases) is alcohol abuse. Other causes of liver disease include obesity, diabetes, genetic and hereditary factors, and viral and bacterial infections such as viral hepatitis. Other potential risks of a blood draw include: AST test results vary based on the laboratory completing the analysis, and the typical ranges reported. Typically the range for normal AST is reported between 10 to 40 units per liter and ALT between 7 to 56 units per liter. Recent research has shown that even mild increases in AST can be a sign of a liver problem that requires further investigation. If the elevation of AST is higher than that of ALT, this is a strong indicator that the damage to the liver is alcohol-, When elevated AST indicates damage to the liver, this damage can come from a variety of different causes, both in the sense of indicating various liver diseases and also in the sense of the diseases being due to various causes. Most clinical laboratories offer bundled blood tests, which often contain all or most of the following: 1. Your doctor may order the AST test to screen you for liver inflammation or injury. are these levels anything to worry about? Normal levels: ALT and AST normal ranges vary depending on lab, in general: ≤ 40 U/L. Your liver plays important roles in your body, including making proteins and removing toxins. When a combination of blood tests including but not limited to a test for elevated AST shows likely damage to the liver, further diagnostic procedures are indicated. Dr. Gurmukh Singh answered 48 years experience Pathology These include tests for ALT, levels of alkaline phosphatase, albumin, and bilirubin. Answered by Dr. Anne Eglash: Several causes: Your ALT, AST, and bilirubin are liver tests. They can use it to check the effectiveness of treatment as well. If it’s being used to monitor liver disease, your doctor may order it periodically while you’re being treated. Because AST can be elevated due to a long list of causes, both pathological and non-pathological, an AST test is always best used in conjunction with other diagnostic tests that can help to pinpoint the actual cause of the test result. Normal values of Alpha Fetoprotein Normal values of ALT, AST, and GGT: Normal values of lactate dehydrogenase Normal values of primary and total bile acids: Paediatric crohn’s disease activity index Pediatric appendicitis score (pas) Other Calculators . It plays an important role in amino acid metabolism. The liver produces and clears cholesterol in the body. Drinking large amounts of alcohol over time can cause any of the liver diseases above with the possible exception of liver cancer. The normal range of values for AST (SGOT) is about 5 to 40 units per liter of serum (the liquid part of the blood). Here are 8 foods that are incredibly healthy, but can cause severe harm if eaten in excess. You may experience some discomfort when the blood sample is drawn. If your potassium spikes suddenly, you may experience difficulty…. You can have mild liver damage and not show any signs or symptoms. Many liver diseases are progressive and the damage from them is irreversible. AST is found in the highest concentrations in your liver, muscles, heart, kidney, brain and red blood cells. Normal serum AST is 14-20 IU per liter in men and 10-36 IU per liter in women. There are a variety of health problems that are associated with higher than normal levels of AST, and this will be elaborated further below . Other tests are typically required to follow up abnormal AST levels. Factors that increase your risk of having liver problems include: Your doctor can use the AST test to check the status of a known liver disorder. In acute hepatitis, AST levels usually stay elevated for about 1–2 months, but can take as long as 3–6 months to return to normal. Too Low AST ALT ratio - check the section below. The interpretation of both an elevated or a normal AST ALT ratio is based on many different factors. Although the normal range of AST and ALT level varies among laboratories and countries, the ratio of AST:ALT is key when it comes to diagnosing liver diseases. It is normally found in the liver, heart, muscles, brain, kidneys, and red blood cells. it may represent an early stage of something more serious), to potentially life-threatening illnesses such as cirrhosis of the liver or liver cancer. The level of AST in the blood is often tested to reveal the presence of liver disease or of damage to the liver. Alcoholic liver disease produces higher elevation of AST than non-alcoholic liver disease in most case. The right lobe…. Healthline Media does not provide medical advice, diagnosis, or treatment. Learn how liver damage can affect cholesterol and what treatments you can explore. Higher-than-normal amounts of this enzyme in your blood may be a sign of a health problem. The AST test measures the amount of AST in your blood that has been released from injured tissue. Aminotransferase (AST) is an enzyme that’s present in various tissues of your body. This will help them determine whether or not your treatment is working. Lifestyle changes can help reduce your risk for fatty liver disease and damage. The test for AST is normally conducted in conjunction with other tests, especially for alanine tranaminase (ALT) and for alkaline phosphatase (ASP). "my alt is 140, ast is 40, and bilirubin is 0.3. i haven't spoken with my doctor because the results came directly from the lab. All rights reserved. Aspartate transaminase (AST) is an enzyme produced in the liver. Too high AST ALT ratio with low levels of AST and ALT. Once you know which form of liver disease is causing the damage to your liver, you and your doctor can work together to come up with a treatment plan that meets your needs. When a blood test for AST indicates elevation above normal range, the. A high AST level is a sign of liver damage, ... Higher-than-normal AST levels can be caused by: Chronic (ongoing) hepatitis; Cirrhosis (long-term damage and scarring of the liver) Some of the other conditions that cause AST levels in your liver to be abnormal are: Other possible reasons for an increased AST level that aren’t related to the liver include: Levels of AST may also be elevated as a result of exposure to drugs or other substances that are toxic to your liver. Elevated AST can be an indicator of liver disease, heart and cardiovascular disease, damage to the skeletal muscles, severe burns, severe loss of blood, acute renal (kidney) failure, acute pancreatitis, diseases of the muscles or the skeletal system, or serious injury of any kind. He found that the ratio decreased in patients with acute viral hepatitis and increased in patients with cirrhosis. Your doctor may order an AST test for several reasons: The symptoms of liver disease that may cause your doctor to order an AST test include: Your doctor may order this test if you’re at high risk of developing liver problems. In some cases, the AST-to-ALT ratio may help your doctor diagnose certain liver diseases. Some of the other conditions that cause AST levels in your liver to be abnormal are: cirrhosis liver cancer autoimmune diseases certain genetic disorders nonalcoholic fatty liver disease (NAFLD) liver trauma in physical injury These can include further blood tests, liver imaging, and liver biopsy.