However, the dosage may range from 5 mg to 40 mg per day. Copyright © 2020 Elsevier B.V. or its licensors or contributors. It’s also available as a generic drug. Other drugs that increase risk of myopathy or rhabdomyolysis include: Digoxin is used to treat heart failure and arrhythmias. They won’t damage your medication. These drugs are often used to treat similar conditions. Usual Adult Dose for Prevention of Cardiovascular Disease Initial dose: 10 mg or 20 mg orally once a day -An initial dose of 40 mg may be used in patients who require a larger reduction in low density lipoprotein (e.g. Store the tablets between 41°F and 86°F (5°C to 30°C). Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking. A class of drugs is a group of medications that work in a similar way. They may also do additional liver and kidney function tests during treatment. Always speak with your doctor or pharmacist about dosages that are right for you. Disclaimer: Our goal is to provide you with the most relevant and current information. Your dose, form, and how often you take it may depend on: This medication has not been studied in children below age 10 years. Secondary objectives were to compare the effects of atorvastatin 40 mg vs 80 mg on HDL-C and triglycerides and also comparing of side effects (myopathy, hepatotoxicity and new onset diabetes mellitus) of both doses. Uses, Benefits, and Food List, Both Red and White Meat Raise Cholesterol Levels, Study Finds, Teens’ Cholesterol Levels Improve, but Only Half Have Ideal Numbers, Hate Statins? Don’t worry about airport x-ray machines. Statin Dose Intensity and Equivalency Chart*. Although none of our patient had significant elevation of CPK. Simvastatin belongs to the drug class known as HMG-CoA reductase inhibitors, also called statins. If you’re taking both drugs, your doctor may want to monitor your digoxin level more closely. Starting: 10 - 20 mg once daily in the evening; Maintenance: 5 - 40 mg once daily; Max: 40 mg once daily; Asian patients: simvastatin may increase risk of myopathy. You should not need a new prescription for this medication to be refilled. There are other drugs available to treat your condition. This information is not a substitute for medical advice. However, because drugs affect each person differently, we can not guarantee that this information includes all possible side effects. Using simvastatin with these drugs can increase the risk of myopathy or rhabdomyolysis. Some may be better suited for you than others. By continuing you agree to the use of cookies. Be sure to avoid doing this when the weather is very hot or very cold. Dosing rosuvastatin at 80 mg exceeds the manufacturer's maximum daily dose and is not approved by the US Food and Drug Administration (FDA). If you don’t take it on schedule: Not taking simvastatin every day, skipping days, or taking doses at different times of the day may also increase your risk for high cholesterol levels, heart attack, or stroke. As Traci says 7 is exceptionally high for triglycerides. Providence offers a range of Medicare Advantage health insurance plans in parts of Oregon and Washington. Always carry the original prescription-labeled container with you. Group A consisted patients who received Atorvastatin 40 mg daily and Group B Atorvastatin 80 mg daily. Studies Find New Drug May Help Lower Cholesterol. This can be harmful or prevent the drug from working well. All rights reserved. At 3 and 6 month follow up, Atorvastatin 40 mg leads to mean LDL cholesterol reduction of 47.18 ± 20.81 & 50.03 ± 18.06 respectively. Cardiovascular health among youths still has…, In a pair of articles published today in the New England Journal of Medicine, researchers tout the potential of bempedoic acid as a powerful new tool…, As far as natural alternatives to chemical ingredients go, capric acid and caprylic triglyceride is one of the cleanest ingredients that you can find…. Vitamin F is not a vitamin in the traditional sense, but a term for two important fats. Simvastatin oral tablet doesn’t drowsiness, but it can cause other side effects. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. https://doi.org/10.1016/j.ihj.2018.01.034. People with a history of alcohol abuse and risk of liver disease should not take this drug. While Atorvastatin 80 mg results in LDL reduction as 50.11 ± 15.85 & 52.30 ± 13.72. You should always consult your doctor or other healthcare professional before taking any medication. The comparison between two doses revealed a non-significant difference (p = .118 & p = .149 respectively). Simvastatin oral tablet is available as a brand-name drug and a generic drug. The difference between groups was significant (p = .045). However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. If you use these drugs with simvastatin, your doctor may lower your dosage of simvastatin. Your glucose is on the high side at 6.9 putting you into the pre diabetes slot. When taken with warfarin, simvastatin can increase the blood-thinning effects of warfarin. Use the pictures above to identify your dose. Pravastatin sodium (Pravachol), commonly called pravastatin, is a member of the statin family of drugs 1 7.It is commonly prescribed to treat high cholesterol levels. If treatment with these drugs is required, the use of simvastatin must be on hold during the course of treatment. Fixed-effect model was used to estimate the risk ratio (RR) and 95% confidence interval (CI) if You may need to show airport staff the pharmacy label for your medication. Monitoring and managing cholesterol levels is a primary focus in preventing heart attacks and strokes. High cholesterol builds up in arteries causing plaques that narrow the passageways available for blood to flow freely to muscles and organs throughout the body. Keep these considerations in mind if your doctor prescribes simvastatin for you. Your doctor should also regularly check your hemoglobin A1C level, which can indicate if your average blood sugar level has been high over an extend period (2–3 months). There is a small risk of increased blood sugar levels and even diabetes from taking simvastatin. You can take simvastatin with or without food. Simvastatin may interact with other medications, Important considerations for taking simvastatin, What Is Vitamin F? The drug information contained here in is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Statins Can Reduce Risk of a Heart Attack for Adults of All Ages, Providence Medicare Advantage: A Guide to Your 2021 Plan Options, Debra Sullivan, Ph.D., MSN, R.N., CNE, COI, What to Do If Your Baby Shows Signs of Pink Eye. The time to find out if Medicare covers ambulance service is before you need one. Don’t double your dose. This study adds to the growing body of…, A new report on childhood cholesterol levels delivers some promising news, but it's not time to cheer. Avoid grapefruit juice while taking simvastatin. How can I tell if the drug is working: Your cholesterol and triglyceride levels should be within healthy levels while taking it. If you miss a dose: If you miss a dose, take the next dose as scheduled. Healthline Media does not provide medical advice, diagnosis, or treatment. An interaction is when a substance changes the way a drug works. 40mg is the usual starting dose for simvastatin. However, these high statin doses are associated with increased adverse effects like liver enzyme elevation, new onset diabetes mellitus and myalgia/myopathy which are related to dose. It comes with serious risks if you don’t take it as prescribed. Simvastatin oral tablet is available as the brand-name drug Zocor. Using simvastatin with colchicine can increase the risk of both myopathy and rhabdomyolysis. At 6 months of follow up, few patients reported myalgia (2 in group A and 7 in Group B). 80 mg dose should be limited to patients who have been taking it for ≥ 12 months without muscle toxicity However, because drugs affect each person differently, we can not guarantee that this list includes all possible dosages. If you become pregnant while taking this drug, call your doctor right away. For people with low thyroid function (hypothyroidism) or diabetes: Simvastatin and other statin drugs can sometimes cause rhabdomyolysis. These drugs block your body from breaking down simvastatin. Taking it with food may reduce nausea. Strengths: 10 mg, 20 mg, 40 mg, and 80 mg; Dosage for prevention of heart disease. For women who are breastfeeding: It isn’t known if simvastatin enters breast milk. This information is not a substitute for medical advice. Disclaimer: Our goal is to provide you with the most relevant and current information. Statins work to reduce the body’s cholesterol production. High cholesterol. However, because drugs interact differently in each person, we can not guarantee that this information includes all possible interactions. High doses -- also called high-intensity statin therapy -- included 40 to 80 milligrams (mg) of atorvastatin (Lipitor) or 20 to 40 mg of rosuvastatin (Crestor) daily.