In the channel-type crystals, the CD molecules are stacked on top of one another similar to coins in a roll. Cl– hydrogen-bonding interactions between the 2-hydroxyl group of emodin and chloride anion. The essential challenge for a successful pharmaceutical product developments is to improve the solubility and dissolution profile of poorly soluble drugs without altering their molecular structure . The cocrystallization approach has been applied to modify the poor solubility profile of the biologically active 1,2,4-thiadiazole derivative (TDZ).Extensive cocrystal screening with a library of coformers resulted in formation of a new solid form of TDZ with vanillic acid in a 1:1 molar ratio. Calcium sulfate (or calcium sulphate) is the inorganic compound with the formula CaSO 4 and related hydrates.In the form of γ-anhydrite (the anhydrous form), it is used as a desiccant.One particular hydrate is better known as plaster of Paris, and another occurs naturally as the mineral gypsum.It has many uses in industry. A cocrystal of diosgenin with piperazine in 2:1 stoichiometry was successfully synthesized. The crystal structures exhibit differences in hydrogen bonding modes and molecular packing arrangements … Which of these elements would you expect to form the following with nickel: (a) A substitutional solid solution having complete solubility Crystal engineering is a new and an incipient approach to incur a pharmaceutical product having improved physicochemical and mechanical properties. In the solid state, α-CD, β-CD, and γ-CD exist as 2 classes of crystal structures, “cage” and “channel.” 6, 7 In the cage-type structure, the CD molecules possess a “herringbone” arrangement, where each CD cavity is blocked by the neighboring CDs. Various π–π interactions dominate the packing structures of 1 and 2. All forms are white solids that are poorly soluble in water. Atomic radius, crystal structure, electronegativity, and the most common valence are given in the following table for several elements; for those that are nonmetals, only atomic radii are indicated. Solubility of D-psicose at 25 °C was 291 g per 100 g water. For one particle to replace another in such a structure is very difficult, unless the particles are almost identical. The polymorphism of cocrystals is not studied as widely as that of single-component crystals. The constituent particles in a solid crystal lattice are packed tightly together in a very specific geometric arrangement. More by Camilla Anelli, Michele R. Chierotti. In this work, two polymorphic forms of a cocrystal of melatonin with piperazine (MLT–PIP I and MLT–PIP II) in a 2:1 stoichiometry were successfully obtained and fully characterized. Camilla Anelli. Investigation of Dimethylammonium Solubility in MAPbBr 3 Hybrid Perovskite: Synthesis, Crystal Structure, and Optical Properties. The solubility of other substances in solids are usually small. The crystal system (orthorhombic), space group (#19, P2 1 2 1 2 1), and number of molecules per unit cell (Z = 4) are the same as those for β-D-fructopyranose, α-L-sorbopyranose, and α-D-tagatopyranose. Camilla Anelli. Department of Chemistry and INSTM, Viale Taramelli 16, Pavia 27100, Italy. The solid form was prepared by liquid assisted grinding, slurry and crystallization methods.