Common Questions and Answers about Crestor side effects depression. The following adverse reactions have been identified during postapproval use of Crestor: arthralgia, fatal and non-fatal hepatic failure, hepatitis, jaundice, thrombocytopenia, depression, sleep … From thousands of reports I have seen a strong association between statin drug use and affective disorders of all kinds. Crestor is also used to lower the risk of stroke, heart attack, and other complications in men 50 years and older or women 60 years and older who have coronary heart disease or other risk … 13 The authors recommend further research … Although this article stresses depression and its most extreme form, suicide, … As propranolol is less of an antihypertensive and used to treat anxiety with more side effects (including severe depression… Selected from data included with permission and copyrighted by First Databank, Inc. However, the association between lipophilic statins and depression is not clear. crestor. Hydrophilic statins can also be linked with depression. Crestor side effects depression.